The mechanisms behind Alzheimer’s disease have eluded scientists for decades. But a new breakthrough points to lithium as a possible explanation—not only does it occur naturally in the brain, but a deficiency causes dementia in mice. This research is one of thousands of projects that have lost funding due to President Trump’s cuts to the National Institutes of Health (NIH). Host Ira Flatow speaks with Alzheimer’s researcher Bruce Yankner about this new finding, and then to epidemiologist Katelyn Jetelina and immunologist Elisabeth Marnik about the country’s “quiet engine of science,” the NIH.Guests: Dr. Bruce Yankner is professor of genetics and neurology at Harvard Medical School in Boston, Massachusetts.Dr. Katelyn Jetelina, epidemiologist and author of the Your Local Epidemiologist newsletter. She’s based in San Diego.Dr. Elisabeth Marnik is an immunologist and Director of Science Education & Outreach at the MDI Biological Laboratory in Bar Harbor, Maine.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

If social media and certain influential podcast hosts are to be believed, cold plunges can do everything from boosting your immune system to reducing inflammation to acting as an antidote for depression. But what does the science say? Joining Host Flora Lichtman to throw at least a few drops of cold water on this science of plunging is biologist François Haman, who studies human performance and cold exposure.And, with the help of the HBO show “Last Week Tonight,” a minor league baseball team in Pennsylvania rebranded themselves the Erie Moon Mammoths. That comes just a few months after the Utah NHL franchise renamed itself the Utah Mammoth as a nod to that state’s paleontological past. So, why are mammoths back? And do they really have what it takes to be a successful team mascot? Paleontologist Advait Jukar joins Host Flora Lichtman to weigh in.Guests: Dr. François Haman is a biologist at the University of Ottawa who studies how the human body responds to extreme environments.Dr. Advait Jukar is the assistant Curator of Vertebrate Paleontology at the Florida Museum of Natural History.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Dr. Masao Tomonaga was only 2 years old when the United States bombed his home city of Nagasaki. He survived, and grew up to become a physician for other survivors, known as hibakusha. He also studied hematology, and his research on leukemia and myelodysplastic syndromes was foundational for understanding how radiation affects the body. On the 80th anniversary of the bombings of Hiroshima and Nagasaki, he speaks with Host Ira Flatow about his life’s work, how hibakusha lived with the medical consequences of the bombs, and his message to the world.Guest: Dr. Masao Tomonaga is a survivor of the atomic bombing of Nagasaki and director emeritus of the Japanese Red Cross Nagasaki Atomic Bomb Hospital.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

The first complete draft of the human genome was published back in 2003. Since then, researchers have worked both to improve the accuracy of human genetic data, and to expand its diversity, looking at the genetics of people from many different backgrounds. Three genetics experts join Host Ira Flatow to talk about a recent close examination of the genomes of 65 individuals from around the world, and how it may help researchers get a better understanding of genomic functioning and diversity.Guests:Dr. Christine Beck is an associate professor of genetics and genome sciences in the University of Connecticut Health Center and the Jackson Laboratory.Dr. Glennis Logsdon is an assistant professor of genetics and a core member of the Epigenetics Institute at the University of Pennsylvania.Dr. Adam Philippy is a Senior Investigator in the Center for Genomics and Data Science Research at the National Human Genome Research Institute at the NIH.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

For almost their entire 4.5 billion-year existence, Earth and its moon have been galactic neighbors. And the moon isn’t just Earth’s tiny sidekick—their relationship is more like that of siblings, and they’re even cut from similar cosmic cloth.Without the moon, Earth and its inhabitants wouldn’t be what they are today: The climate would be more extreme, lunar tides wouldn’t have given rise to life on Earth, biological rhythms would be off-beat, and even timekeeping and religion would have evolved differently. The new book Our Moon: How Earth’s Celestial Companion Transformed The Planet, Guided Evolution, And Made Us Who We Are explores how our existence is tied to the moon’s.Ira Flatow and guest host Sophie Bushwick chat with journalist and author Rebecca Boyle about how the moon came to be, how it transformed life on Earth, and how our relationship with it is changing.Guest: Rebecca Boyle is a journalist and author of Our Moon: How Earth’s Celestial Companion Transformed The Planet, Guided Evolution, And Made Us Who We Are. She’s based in Colorado Springs, Colorado.Transcript available at sciencefriday.com.  Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Paleontologists have identified an ancient reptile with a towering crest made not of skin, or scales, or feathers, or antler—but something else entirely. It’s some kind of integumentary outerwear we’ve never seen before. The small creature sporting the curious crest was named Mirasaura grauvogeli, and it lived during the Middle Triassic period, about 247 million years ago, just before dinosaurs evolved. Host Flora Lichtman talks to evolutionary biologist Richard Prum about this dramatic dorsal mystery and what it tells us about the evolution of dinosaurs, birds, and feathers. Plus, how fast did dinosaurs run? It turns out that the equation scientists have been using for five decades to estimate dinosaur speeds is not completely accurate. To understand what this could mean for velociraptor velocities, T. rex tempos, and spinosaurus speeds, Flora talks with paleobiologist Peter Falkingham.Guests: Dr. Richard Prum is a professor of ecology and evolutionary biology and head curator of ornithology at the Peabody Museum of Natural History at Yale University in New Haven, Connecticut. He previously chaired Yale’s Department of Ecology and Evolutionary Biology.Dr. Peter Falkingham is a professor of paleobiology at Liverpool John Moores University in England.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

The Trump administration has proposed cutting NASA’s budget by almost 25% and shutting down 19 currently operating science missions. On July 21, several hundred current and former employees of the space agency released an official letter of dissent, titled “The Voyager Declaration,” arguing against “rapid and wasteful changes which have undermined our mission.” Retired NASA astronaut Cady Coleman joins Host Flora Lichtman to explain why she felt compelled to add her signature to the letter of dissent.Guest:Dr. Cady Coleman is a retired NASA astronaut and the author of Sharing Space: An Astronaut’s Guide to Mission, Wonder, and Making Change. She’s based in Shelburne Falls, Massachusetts.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

The EPA recently announced that it’s going to shut down its scientific research arm, called the Office of Research and Development. Since the agency was founded nearly 55 years ago, it’s had in-house scientists researching things like pollutants in our air and water, and the risks posed by toxic chemicals. That research informs the EPA’s guidelines and standards.Host Flora Lichtman talks with Jennifer Orme-Zavaleta, who spent 40 years working at the EPA, about the importance of the Office’s research and what losing it means for public health and the environment.Guest: Dr. Jennifer Orme-Zavaleta spent 40 years working at the Environmental Protection Agency. She was the principal deputy assistant administrator for EPA’s Office of Research and Development.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

About 7% of veterans experience post-traumatic stress disorder (PTSD), and that number can be closer to 30% for those who have served in a war zone.  But PTSD has been treated pretty much the same way since the disorder was first recognized roughly four decades ago: Patients are instructed to revisit their trauma until the memory no longer creates an emotional response. This process can be so harrowing that over half of veterans are unable to complete the full course of treatment. But what if there was a way for PTSD treatment to be virtually painless?Host Flora Lichtman talks with Yasmin Tayag, staff writer at The Atlantic, who explored a controversial treatment called Reconsolidation of Traumatic Memories, and the challenges of even studying a treatment that bucks conventional wisdom.  Guest: Yasmin Tayag is a staff reporter for The Atlantic.Transcripts for each episode are available within 1-3 days at sciencefriday.com.  Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

For decades, astronomers have been trying to nail down the value of the Hubble constant—a measure of how fast the universe is expanding. But some cosmologists say there’s evidence that the universe is expanding faster than physics can explain, and our current models of it might be broken. Hosts Flora Lichtman and Ira Flatow talk with Wendy Freedman and Dan Scolnic, two cosmologists with different takes on this constant controversy.Guests: Wendy Freedman, a former team leader of the Hubble Key Project, is a professor of astronomy and astrophysics at the University of Chicago in Chicago, Illinois.Dr. Dan Scolnic is a cosmologist and associate professor of physics at Duke University in North Carolina.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Oceanographer Victoria Orphan’s dream was coming true. She was sitting in the Alvin submersible, on one of its deepest science dives ever. But the trip was anything but smooth sailing. Victoria takes us inside the sub, where her dream turns nightmarish as things start to go wrong, and Alvin pilot Nick O’Sadcia works frantically to troubleshoot. Oceanographer Shana Goffredi, who’s also Victoria’s wife, tells us about the tense scene unfolding on the ship miles above, as they wait for word from the sub. “The Leap” is a 10-episode audio series that profiles scientists willing to take big risks to push the boundaries of discovery. It has premiered on Science Friday’s podcast feed every Monday since May 12. This is the final episode of the 2025 season.“The Leap” is a production of the Hypothesis Fund, brought to you in partnership with Science Friday.Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Researchers found a new sea spider with a giant nose, leg cannons, and—most remarkably—a novel way of surviving in the lightless, freezing environment miles below the sea surface. These oceanic arthropods are powered by methane that seeps out of the ocean floor.Biologist Shana Goffredi joins Host Flora Lichtman to tell us more about the discovery and explain how we’re connected to these little beasts.Guest: Dr. Shana Goffredi is a biology professor at Occidental College in Los Angeles, CA.Transcripts for each episode are available within 1-3 days at sciencefriday.com.  Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.